Validating reports of poor childhood memory

Previous research has shown that higher levels of allostatic load are associated with an increased likelihood of a negative health event, such as a heart attack or stroke, and with declines in physical or cognitive functioning.reported higher amounts of parental warmth and affection in childhood had lower multi-system health risks than abused individuals who didn't experience such warmth and affection.

Conversely, individuals reporting low levels of love and affection and high levels of abuse in childhood had the highest multi-system risk in adulthood.

The researchers suggest that toxic childhood stress alters neural responses to stress, boosting individuals' emotional and physical arousal to threats and making it more difficult for that reaction to be shut off."Our findings highlight the extent to which these early childhood experiences are associated with evidence of increased biological risks across nearly all of the body's major regulatory systems," said the paper's senior author, Teresa Seeman, a professor of medicine in the division of geriatrics at the David Geffen School of Medicine at UCLA and a professor of epidemiology at UCLA's Fielding School of Public Health.

But research into the physical effects of abuse has so far focused on separate, individual systems rather than on the body as a whole.Now, a UCLA-led study examines for the first time the effects that abuse and a lack of parental affection have across the body's entire regulatory system and finds a strong biological link for how these negative early-life experiences affect physical health.But the researchers also found that parental warmth can mitigate some the health impact of early abuse."Our findings suggest that there may be a way to reduce the impact abuse has, at least in terms of physical health," said Judith E.Carroll, a research scientist at the Cousins Center for Psychoneuroimmunology at UCLA and lead author of the study."If the child has love from parental figures, they may be more protected from the impact of the abuse on adult biological risk for health problems than those who don't have that loving adult in their life."The researchers studied 756 adults who had participated in the Coronary Artery Risk Development in Young Adults (CARDIA) study They measured 18 biological markers of health risk, including blood pressure, heart rate, stress hormones, cholesterol, waist circumference, inflammation and blood-sugar regulation.

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They added up participants' risks across these markers to create a summary index called "allostatic load." Values at the upper range across these markers indicated they were at higher biological risk for disease.

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